16α-Hydroxy Steroids
نویسندگان
چکیده
منابع مشابه
Rearrangement of 14/3-Hydroxy-12ß-sulfoxy-steroids to 13,17-Seco-12,17-cyclo-steroids; a 2D-NMR Analysis
During our work on cardiaoctive steroids we studied the elimination of the 12/3-sulfoxy-group. It is well known that 12/J-tosyloxyor 12/3-mesyloxysteroids with C/D-trans juncture undergo elimination to yield C-nor-D-homo steroids with 12(13) or 13(18) double bonds [1—6]. The same rearrangement product was obtained by the reaction of a 12/3-tosyloxycardenolide [7] with C/D-eis juncture. No GrobF...
متن کاملMicrobial Hydroxylation of 16α, 17α-Epoxyprogesterone by Penicillium Decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کامل1β,15α-Dihydroxy-16α,17-epoxypregn-4-ene-3,20-dione
The title mol-ecule, C21H28O5, is composed of three six-membered rings (A/B/C) and a five-membered ring (D). Ring A adopts a 1α-sofa conformation, while rings B and C adopt chair conformations. Cyclo-pentane ring D adopts a 14α-envelope conformation. In the crystal, O-H⋯O hydrogen bonds lead to the formation of ribbons running along the a axis. The structure is further consolidated by C-H⋯O int...
متن کاملMicrobial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کاملRegio- and stereospecific hydroxylation of various steroids at the 16α position of the D ring by the Streptomyces griseus cytochrome P450 CYP154C3.
Cytochrome P450 monooxygenases (P450s), which constitute a superfamily of heme-containing proteins, catalyze the direct oxidation of a variety of compounds in a regio- and stereospecific manner; therefore, they are promising catalysts for use in the oxyfunctionalization of chemicals. In the course of our comprehensive substrate screening for all 27 putative P450s encoded by the Streptomyces gri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69461-x